EFFECTS OF EXPERIMENTAL NERVE ROOT COMPRESSION ON ARTERIAL BLOOD FLOW VELOCITY IN THE SEVENTH LUMBAR SPINAL GANGLION OF THE DOG: MEASUREMENT USING INTRAOPERATIVE DOPPLER ULTRASONOGRAPHY     

Jeryl C.  Jones  DVM  PHD  Judith A.  Hudson  DVM  PhD  Donald C.  Sorjonen  DVM  MS  Charles E.  Hoffman  CVT  BS  LATG  Kyle G.  Braund  BVS  MVS  PhD  James C.  Wright  DVM  MS  PhD  Phillip D.  Garrett  DVM  MS  Jan E.  Bartels  DVM  MS 《Veterinary radiology & ultrasound》1996,37(2):133-140

Intraoperative Doppler ultrasonography was used to measure the effects of four experimental nerve root compression treatments (central compression, central-plus-lateral compression, lateral compression, and compression release) on arterial blood flow velocities in the seventh lumbar spinal ganglion of three dogs. Graphed blood flow velocity changes (change = treatment value − pretreatment value) were below baseline during the first three compression treatments and above baseline following compression release. Mean blood flow velocity changes for both central-plus-lateral compression and lateral compression differed (p ≤ 0.05) from changes for central compression. Changes for central-plus-lateral compression did not differ (p > 0.05) from changes for lateral compression. Changes among the first three compression treatments differed (p ≤ 0.05) from changes for compression release. No histologic abnormalities were identified in compressed nerve tissues, compared to contralateral controls. These findings indicate that stenosis within the L7-S1 intervertebral foramen may cause ischemia of the L7 spinal ganglion in dogs.  相似文献   

Blood buffering in sedentary miniature horses after administration of sodium bicarbonate in single doses of varying amounts     

C.D. Corn BS  G.D. Potter PhD  T.W. Odom PhD  O.C. Jenkins PhD 《Journal of Equine Veterinary Science》1993,13(10)

Blood acid-base and electrolyte status was studied in four sedentary Miniature Horses treated with 200, 300, 400 and 500 mg of sodium bicarbonate (NaHCO₃) per kg of body weight (BW). Arterial blood was collected before treatment with NaHC0₃ and each hour for 5 h after treatment. All treatments resulted in an increase in blood pH, bicarbonate (HCO₃⁻) concentration and base excess (BE) by 1 h post-dosage, which continued through the 5th hour (P < .05). Treatment with 200 mg NaHC0₃/kg BW resulted in less elevated blood HCO₃⁻ concentrations (P < .03) and BE values (P < .01) when compared to the other treatments. Following dosing with NaHCO₃, plasma Na⁺ concentrations increased among all treatments but declined to initial values by 3 h post-treatment. The 200 mg NaHCO₃/kg BW dosage resulted in the smallest increases in plasma Na⁺ concentrations (P < .03). Both plasma K⁺ and Ca⁺⁺ concentrations were lower (P < .05) among all treatment groups 1 h post-dosage but returned to initial values by 5 h and 3 h posttreatment, respectively, with no differences (P >.05) among treatments. All NaHCO₃ dosages increased blood buffering capacity as indicated by increased blood pH, HCO₃⁻ concentration and BE. Maximum blood pH, HCO⁻₃ concentration and BE was reached using a dosage of 300 mg NaHCO₃/kg BW. Also, all treatments altered the plasma electrolyte concentrations.  相似文献   

Pharmacokinetics of procainamide hydrochloride in dogs     

M G Papich  L E Davis  C A Davis  B C McKiernan  S A Brown 《American journal of veterinary research》1986,47(11):2351-2358

Pharmacokinetics of procainamide hydrochloride were studied in 2 groups of dogs. In a group of 6 dogs, procainamide was administered IV at a small dose of 8 mg/kg (group 1), and blood samples were obtained for 3.5 hours. In another group of 6 dogs, procainamide was administered IV and orally at an average dose of 25.5 mg/kg (group 2) in a crossover manner. Blood samples were obtained for 48 hours. In 2 dogs (previously used in part II), N-acetylprocainamide (NAPA) was administered IV at a dose of 10 mg/kg. Plasma samples were assayed for procainamide by fluorescence polarization immunoassay, and NAPA samples were assayed by high-performance liquid chromatography. In group 1, the elimination of procainamide was described by a 1-compartment, open pharmacokinetic model. The elimination half-life was 2.43 hours, the apparent volume of distribution was 1.44 L/kg, and the systemic clearance was 0.412 L/kg/hr. In group 2, 2 of the 6 dogs were described by a 1-compartment model, and 4 of the 6 dogs were described with a 2-compartment pharmacokinetic model. The elimination half-life for the IV dosage was 2.85 hours, the apparent volume of distribution was 2.13 L/kg, and the systemic clearance was 0.519 L/kg/hr. For the orally administered dose, the bioavailability was 85%, and the absorption half-life was 0.5 hours. There was no evidence of acetylation of procainamide to NAPA or deacetylation of NAPA to procainamide. The estimated elimination half-life of NAPA was 4.7 hours.  相似文献   

Preliminary Results of Clinical Renal Allograft Transplantation in the Dog and Cat   总被引：1，自引：0，他引：1  

C. R. Gregory DVM    I. M. Gourley DVM  PhD    N. J. Taylor BS    T. W. Broaddus DVM  PhD    R. B. Olds DVM  J. D. Patz BS 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1987,1(2):53-60

Renal allograft transplantation was performed as treatment for terminal renal failure in six veterinary patients. Three patients failed to survive the postsurgical period, one patient died due to acute allograft rejection, one patient died subsequent to complications of previous parenteral hyperalimentation and infection, and one patient was euthanatized due to the inability of the clients to maintain the effort necessary to manage a transplant recipient. Further clinical studies are necessary to determine if renal transplantation with cyclosporine (cyclosporin A)/prednisolone immunosuppression has the potential to provide practical treatment of terminal renal disease in clinical veterinary medicine. Pharmacologic and immunologic monitoring of transplant recipients with individualized immunosuppression is imperative. Careful surveillance is necessary to identify and eliminate nosocomial sources of infection. Candidates for transplantation cannot be critically ill or malnourished prior to surgery, and pet owners must be prepared for the financial and time commitments associated with caring for a renal allograft recipient.  相似文献   

Chlorhexidine Gluconate Versus Chloroxylenol for Preoperative Skin Preparation in Dogs     

W. PRESTON STUBBS DVM    JAMIE R. BELLAH DVM  Dipiomate ACVS    DONNA VERMAAS-HEKMAN BS    BARBARA PURICH MS  PAUL S. KUBILIS MS 《Veterinary surgery : VS》1996,25(6):487-494

The efficacy of 3% chloroxylenol (PCMX) or 4% chlorhexidine gluconate (CG) for preoperative skin preparation was assessed in 100 dogs undergoing clean or clean-contaminated surgical procedures. Replication Organism Detection and Counting (RODAC) plates were used to quantify skin bacteria colony forming units (CFU) at the operative site before and after skin preparation and immediately postoperatively. Reduction of CFU after skin preparation and immediately postoperatively was significant for each agent. However, CFU levels were significantly lower in the CG group than in the PCMX group after surgical preparation, regardless of initial CFU numbers. No significant difference in CFU counts was observed between antiseptic groups postoperatively. Within-group comparisons showed PCMX to be significantly less efficacious when the prescrub CFU number was greater than 1,000. Bacterial reduction was similar in the CG group regardless of prescrub CFU levels. The number of negative cultures after skin preparation was significantly greater with CG than with PCMX. Chlorhexidine gluconate also had fewer cultures with heavy bacterial growth (>5 CFUs) after surgical preparation. There was no significant difference between antiseptics in the number of negative cultures or cultures with more than 5 CFUs immediately after surgery. The number of skin reactions and postoperative wound infections that occurred with each technique were similar. Three percent PCMX, as used in this study, was less effective than 4% CG in its immediate antimicrobial activity, however, this difference was not associated with an increased wound infection rate.  相似文献   

FRACTURED SCLERAL OSSICLES IN A RED TAIL HAWK     

Denise M.  Lindley  BS  DVM  John T.  Hathcock  DVM  MS  William W.  Miller  DVM  MS  M. Nina  DiPinto  VMD 《Veterinary radiology & ultrasound》1988,29(5):209-212

Following head trauma, the left globe of a Red Tail Hawk showed demonstrable indentation on palpation. Recurrent anterior chamber collapse and reformation dependent on head position was the most significant clinical finding. A fracture of the scleral ossicles in the caudal portion of the scleral ring was identified in the rostrocaudal radiograph of the skull. Conservative management of the fracture resulted in phthisis bulbi. Fractured scleral ossicles have been shown radiographically in the enucleated globe but have not been previously demonstrated in the eye of the living bird.  相似文献   

Applied Pharmacology for the Veterinary Technician by Boyce P. Wanamaker and Christy L. Pettes     

CRAIG CORNELL BS  RVT 《Veterinary surgery : VS》1996,25(5):417-417

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Circulating concentrations of immunoreactive inhibin and FSH during the estrous cycle of mares     

D.R. Bergfelt MS  B.G. Mann BS  N.B. Schwartz PhD  O.J. Ginther VMD  PhD 《Journal of Equine Veterinary Science》1991,11(6):319-322

A heterologous radioimmunoassay developed to measure inhibin in rat plasma was validated and used to characterize changes in peripheral concentrations of immunoreactive inhibin (ir-inhibin) in relation to follicle stimulating hormone (FSH) concentrations during the estrous cycle of mares. The primary antiserum used in the assay was developed against a synthetic porcine inhibin -subunit [(1-26)-Gly-Tyr] fragment. The same synthetic peptide was used for preparation of standards and tracer. Slopes of the dose-response curves for pooled estrus and diestrus mare plasma and equine follicular fluid were similar to the slopes for the porcine inhibin -subunit standard curve and porcine follicular fluid dose-response curve. Twelve mares were bled once daily beginning when diameter of the largest follicle reached ≤25 mm and continuing until 3 days after the end of an interovulatory interval (ovulation=Day 0). Each of the 12 interovulatory intervals were normalized to the mean length of the interovulatory interval (22.2 days; range, 19 to 26). There was an effect of day for concentrations of ir-inhibin (P<0.001) and FSH (P<0.006). Significant mean changes were as follows: 1) ir-inhibin decreased between Days 0 and 1, whereas FSH increased between Days 0 and 5; and 2) ir-inhibin increased between Days 7 and 12, whereas FSH decreased between Days 11 and 14. Mean concentrations of ir-inhibin and FSH were negatively correlated (r=-0.548; P<0.002). In conclusion, mean peripheral concentrations of ir-inhibin and FSH were inversely related during the estrous cycle of mares.  相似文献   

Transsphenoidal surgery: accuracy of an image‐guided neuronavigation system to approach the pituitary fossa (sella turcica)          下载免费PDF全文

Tina J. Owen DVM  Dipl ACVS  Annie V. Chen DVM  MS  Dipl ACVIM  Stephen Frey PhD  Linda G. Martin DVM  MS  Dipl ACVECC  Tobin Kalebaugh BS 《Veterinary surgery : VS》2018,47(5):664-671

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Evaluation of the effects of initial water temperature and curing time on fiberglass cast strength          下载免费PDF全文

Marcos Pérez‐Nogués LV  MSc  Julie E. Dechant DVM  MS  DACVS  DACVECC  Tanya Garcia‐Nolen BS  MS  Susan M. Stover DVM  PhD  DACVS 《Veterinary surgery : VS》2018,47(6):809-816

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